All facts you should know about combination of Cialis and grapefruit

Many men and women love grapefruit. This beautiful fruit (also known as Citrus Paradisi) is considered a good tool to speed up the weight loss process and a component of a healthy diet. It contains a lot of vitamins, minerals, antioxidants and other components. These are advantages of this citrus. Grapefruit downside is that this fruit is able to influence the efficiency of certain medicaments. The group of medications includes Cialis, a progressive and popular drug with prolonged action, which is often used to cure erection problems. Many patients choose this medicament because it acts during 36 hours compared to other similar medicaments acting only about 6 hours.

The data of scientific studies

According to the experiment, conducted by M. Kinzig-Schippers & A. Jetter in 2002 in the University of Köln, Germany, consumption of grapefruit or its juice together with taking Viagra (main active ingredient – sildenafil) increases the absorption of the main agent by 23 percent. Scientists say that such a large increase in the concentration of the medicament might be dangerous for patients. Grapefruit interacts not only with Viagra. It can cause dangerous interactions with other PDE5 inhibitors, such as Cialis. What might happen if you combine grapefruit with Cialis? The level of the active agent of this medicament can enlarge in your blood, which, in turn, can cause more adverse effect than usual. For example, some male persons experienced a significant decrease of blood pressure when combining Cialis and Citrus Paradisi.
Interestingly, the fruit can affect not only the action of inhibitors on PDE5, it can also have the negative influence on the action of other medical remedies. In 1989, scientists from Canada investigated the effect of a medical remedy that enlarged blood pressure (an antihypertensive medicament called Plendil). Scientists were surprised when they saw that only one glass of juice of grapefruit, enlarged the effect of the medicament and made the latter dangerous for patients.

Causes of dangerous effect of the grapefruit

Scientists have found that the fruit or its juice inhibit the action of certain enzymes in the h body, which are necessary tools for reducing the effects of some medicaments and toxins that enter the body. Substances contained in the fruit block the action of the above enzymes when ingested. Therefore, the intestine absorbs more of the active ingredient of the medicament. Juice from other citrus fruits may also interact with Cialis. However, their effect is much less expressed than in the case of Citrus Paradisi.

How to prevent dangerous interactions?

It is well known that Cialis is effective for thirty-six hours. The fruit may remain in the body for up to 24 hours. Therefore, it is better not to use this fruit in the case of continuous (daily) treatment with Cialis. If you take Cialis “as needed”, do not eat grapefruit for 24 hours before taking the pill. Also, avoid consumption of the red fruit 36 hours after taking the medicament.